Article
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations.
Nature communications - 31 Jul 2020
Wang Ying, Guo Jing, Ni Guiyan, Yang Jian, Visscher Peter M, Yengo Loic
Abstract excerpt
Polygenic scores (PGS) have been widely used to predict disease risk using variants identified from genome-wide association studies (GWAS). To date, most GWAS have been conducted in populations of European ancestry, which limits the use of GWAS-derived PGS in non-European ancestry populations. Here, we derive a theoretical model of the relative accuracy (RA) of PGS across ancestries. We show through extensive...
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