Article

Causal variant capture in genotype discovery approaches drives polygenic prediction performance across traits and populations

2025-03-18

Abstract excerpt

Polygenic scores (PGS) are widely used to estimate genetic predisposition to complex traits by aggregating the effects of common variants into a single measure. They hold promise in identifying individuals at increased risk for diseases, allowing earlier screening and interventions. Genotyping arrays, commonly used for PGS computation, are affordable and computationally efficient, while whole-genome sequencing (WG...

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Literature Corpus work: 32a2247a-06ad-5800-bb42-7dab1d447721
DOI: 10.1101/2025.03.18.644029

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