Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal evolution driven by superdriver mutations.

BMC evolutionary biology - 20 Jul 2020

Grossmann Patrick, Cristea Simona, Beerenwinkel Niko

Abstract excerpt

BACKGROUND: Tumors are widely recognized to progress through clonal evolution by sequentially acquiring selectively advantageous genetic alterations that significantly contribute to tumorigenesis and thus are termned drivers. Some cancer drivers, such as TP53 point mutation or EGFR copy number gain, provide exceptional fitness gains, which, in time, can be sufficient to trigger the onset of cancer with little or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Neoplasms
Share to Point Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Time Factors

Share to Disease Progression

Share to Biological Evolution

Share to Clonal Evolution

Source

Open in PubMed Open full text

Identifiers

PMID: 32689942
DOI: 10.1186/s12862-020-01647-y
PMCID: PMC7370525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal evolution driven by superdriver mutations.PMID 32689942Read ↗

Accumulation of driver and passenger mutations during tumor progression.Semantic proximity Read ↗

Interplay of Driver, Mini-Driver, and Deleterious Passenger Mutations on Cancer ProgressionSemantic proximity Read ↗

Evolving copy number gains promote tumor expansion and bolster mutational diversification.Semantic proximity Read ↗

Revisiting the tumorigenesis timeline with a data-driven generative model.Semantic proximity Read ↗

A modelling framework for cancer ecology and evolution.Semantic proximity Read ↗

The evolutionary theory of cancer: challenges and potential solutions.Semantic proximity Read ↗

Spatial evolution of tumors with successive driver mutations.Semantic proximity Read ↗

Population dynamics is a cancer driver.Semantic proximity Read ↗

Non-cell-autonomous effects yield lower clonal diversity in expanding tumors.Semantic proximity Read ↗

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)Semantic proximity Read ↗

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).Semantic proximity Read ↗

Modeling the Subclonal Evolution of Cancer Cell Populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.