Article
Revisiting the tumorigenesis timeline with a data-driven generative model.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jan 2020
Lahouel Kamel, Younes Laurent, Danilova Ludmila, Giardiello Francis M, Hruban Ralph H, Groopman John, Kinzler Kenneth W, Vogelstein Bert, Geman Donald, Tomasetti Cristian
Abstract excerpt
Cancer is driven by the sequential accumulation of genetic and epigenetic changes in oncogenes and tumor suppressor genes. The timing of these events is not well understood. Moreover, it is currently unknown why the same driver gene change appears as an early event in some cancer types and as a later event, or not at all, in others. These questions have become even more topical with the recent progress brought by...
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