The evolutionary theory of cancer: challenges and potential solutions.

Abstract excerpt

The clonal evolution model of cancer was developed in the 1950s-1970s and became central to cancer biology in the twenty-first century, largely through studies of cancer genetics. Although it has proven its worth, its structure has been challenged by observations of phenotypic plasticity, non-genetic forms of inheritance, non-genetic determinants of clone fitness and non-tree-like transmission of genes. There is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clonal Evolution
• Share to Mutation
• Share to Neoplasms