Article
Accumulation of driver and passenger mutations during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010
Bozic Ivana, Antal Tibor, Ohtsuki Hisashi, Carter Hannah, Kim Dewey, Chen Sining, Karchin Rachel, Kinzler Kenneth W, Vogelstein Bert, Nowak Martin A
Abstract excerpt
Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the current study, we provide a mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver...
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