Article
Non-cell-autonomous effects yield lower clonal diversity in expanding tumors.
Scientific reports - 11 Sept 2017
Tissot Tazzio, Thomas Frédéric, Roche Benjamin
Abstract excerpt
Recent cancer research has investigated the possibility that non-cell-autonomous (NCA) driving tumor growth can support clonal diversity (CD). Indeed, mutations can affect the phenotypes not only of their carriers ("cell-autonomous", CA effects), but also sometimes of other cells (NCA effects). However, models that have investigated this phenomenon have only considered a restricted number of clones. Here, we...
Topics
Join the communities discussing this publication.