Modeling the Subclonal Evolution of Cancer Cell Populations.

Abstract excerpt

Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected dynamics and extent to which these divergent subclonal expansions occur. Here, we develop and implement more than 88,000 instances of a stochastic evolutionary model simulating genetic drift and neoplastic progression. Under different combinations of population...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Clonal Evolution
• Share to Colorectal Neoplasms
• Share to Glioblastoma