Article

Interplay of Driver, Mini-Driver, and Deleterious Passenger Mutations on Cancer Progression

2016-10-30

Abstract excerpt

Cancer is caused by the accumulation of a critical number of somatic mutations (drivers) that offer fitness advantage to tumor cells. Moderately deleterious passengers, suppressing cancer progression, and mini-drivers, mildly beneficial to tumors, can profoundly alter the cancer evolutionary landscape. This observation prompted us to develop a stochastic evolutionary model intended to probe the interplay of driver...

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Literature Corpus work: 28b1aaed-c50b-54e7-8e35-6e5ae2daea0a
DOI: 10.1101/084392

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