Article
The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).
eLife - 17 Dec 2024
Zhang Lingjie, Deng Tong, Liufu Zhongqi, Liu Xueyu, Chen Bingjie, Hu Zheng, Liu Chenli, Tracy Miles E, Lu Xuemei, Wen Hai-Jun, Wu Chung-I
Abstract excerpt
Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many mutations. At the nucleotide level, such mutations are cancer-driving nucleotides (CDNs). The full sets of CDNs are necessary, and perhaps even sufficient, for the understanding and treatment of each cancer patient. Currently, only a small fraction of CDNs is known as most mutations accrued in tumors are not drivers. We now...
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