The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

Abstract excerpt

<h4>ABSTRACT</h4> Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many mutations. At the nucleotide level, such mutations are Cancer Driving Nucleotides (CDNs). The full sets of CDNs are necessary, and perhaps even sufficient, for the understanding and treatment of each cancer patient. Currently, only a small fraction of CDNs is known as most mutations accrued in tumors are not...

Topics

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• Carcinogenesis
• Evolution, Molecular
• Genomics
• Models, Genetic
• Mutation
• Neoplasms
• Nucleotides
• Point Mutation

Identifiers and source

Literature Corpus work

dbbcea9b-3ea8-58c1-97cb-561a3c711788

DOI

10.1101/2024.05.29.596366