Article
Evaluating polygenic risk scores in assessing risk of nine solid and hematologic cancers in European descendants.
International journal of cancer - 15 Dec 2020
Choi Jungyoon, Jia Guochong, Wen Wanqing, Long Jirong, Zheng Wei
Abstract excerpt
Genome-wide association studies (GWAS) have identified many genetic risk variants for cancers. The utility of these variants in assessing risk of esophageal, gastric and endometrial cancers, as well as melanoma, glioma, diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphoid leukemia and multiple myeloma, has not been adequately investigated. We constructed a site-specific polygenic risk score (PRS)...
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