Article
Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study.
eLife - 27 Mar 2023
Ho Peh Joo, Tan Iain BeeHuat, Chong Dawn Qingqing, Khor Chiea Chuen, Yuan Jian-Min, Koh Woon-Puay, Dorajoo Rajkumar, Li Jingmei
Abstract excerpt
Background: To evaluate the utility of polygenic risk scores (PRSs) in identifying high-risk individuals, different publicly available PRSs for breast (n=85), prostate (n=37), colorectal (n=22), and lung cancers (n=11) were examined in a prospective study of 21,694 Chinese adults. Methods: We constructed PRS using weights curated in the online PGS Catalog. PRS performance was evaluated by distribution,...
Topics
- Adult
- Humans
- Male
- Female
- Prospective Studies
- East Asian People
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Risk Factors
- Lung Neoplasms
- Multifactorial Inheritance
- Colorectal Neoplasms