Article
Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.
Nature communications - 12 Feb 2021
Graff Rebecca E, Cavazos Taylor B, Thai Khanh K, Kachuri Linda, Rashkin Sara R, Hoffman Joshua D, Alexeeff Stacey E, Blatchins Maruta, Meyers Travis J, Leong Lancelote, Tai Caroline G, Emami Nima C, Corley Douglas A, Kushi Lawrence H, Ziv Elad, Van Den Eeden Stephen K, Jorgenson Eric, Hoffmann Thomas J, Habel Laurel A, Witte John S, Sakoda Lori C
Abstract excerpt
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969 cases, 359,802 controls). Within cohorts, each PRS is evaluated in multivariable logistic regression models against...
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