Article

The landscape of interactions between cancer polygenic risk scores and somatic alterations in cancer cells

2020-09-29

Abstract excerpt

Over the last 15 years we have identified hundreds of inherited variants that increase the risk of developing cancer. Polygenic risk scores (PRS) summarize the genetic risk of each individual by accounting for the unique combination of risk alleles in their genome. So far, most studies of PRS in cancer have focused on their predictive value: i.e. to what extent the PRS can predict which individuals will develop a...

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Literature Corpus work: 5753981b-e411-587f-9c5c-5499231cd99b
DOI: 10.1101/2020.09.28.316851

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