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Article

Polygenic scores in cancer.

Nature reviews. Cancer - 1 Sept 2023

Yang Xin, Kar Siddhartha, Antoniou Antonis C, Pharoah Paul D P

Abstract excerpt

Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer have been identified. The relative risk associated with individual variants is small and of limited clinical significance. However, the combined effect of multiple risk variants as captured by polygenic scores (PGSs) may be much greater and therefore provide...

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PMID: 37479830
DOI: 10.1038/s41568-023-00599-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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