Article
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Nature communications - 3 Jul 2020
Zhang Yan Dora, Hurson Amber N, Zhang Haoyu, Choudhury Parichoy Pal, Easton Douglas F, Milne Roger L, Simard Jacques, Hall Per, Michailidou Kyriaki, Dennis Joe, Schmidt Marjanka K, Chang-Claude Jenny, Gharahkhani Puya, Whiteman David, Campbell Peter T, Hoffmeister Michael, Jenkins Mark, Peters Ulrike, Hsu Li, Gruber Stephen B, Casey Graham, Schmit Stephanie L, O'Mara Tracy A, Spurdle Amanda B, Thompson Deborah J, Tomlinson Ian, De Vivo Immaculata, Landi Maria Teresa, Law Matthew H, Iles Mark M, Demenais Florence, Kumar Rajiv, MacGregor Stuart, Bishop D Timothy, Ward Sarah V, Bondy Melissa L, Houlston Richard, Wiencke John K, Melin Beatrice, Barnholtz-Sloan Jill, Kinnersley Ben, Wrensch Margaret R, Amos Christopher I, Hung Rayjean J, Brennan Paul, McKay James, Caporaso Neil E, Berndt Sonja I, Birmann Brenda M, Camp Nicola J, Kraft Peter, Rothman Nathaniel, Slager Susan L, Berchuck Andrew, Pharoah Paul D P, Sellers Thomas A, Gayther Simon A, Pearce Celeste L, Goode Ellen L, Schildkraut Joellen M, Moysich Kirsten B, Amundadottir Laufey T, Jacobs Eric J, Klein Alison P, Petersen Gloria M, Risch Harvey A, Stolzenberg-Solomon Rachel Z, Wolpin Brian M, Li Donghui, Eeles Rosalind A, Haiman Christopher A, Kote-Jarai Zsofia, Schumacher Fredrick R, Al Olama Ali Amin, Purdue Mark P, Scelo Ghislaine, Dalgaard Marlene D, Greene Mark H, Grotmol Tom, Kanetsky Peter A, McGlynn Katherine A, Nathanson Katherine L, Turnbull Clare, Wiklund Fredrik, Chanock Stephen J, Chatterjee Nilanjan, Garcia-Closas Montserrat
Abstract excerpt
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of...
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