Article

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

2019-08-09

Abstract excerpt

We analyzed summary-level data from genome-wide association studies (GWAS) of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) contributing to risk, as well as the distribution of their associated effect sizes. All cancers evaluated showed polygenicity, involving at a minimum thousands of independent susceptibility variants. For some malignancie...

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Literature Corpus work: e580a717-f3d7-5a57-9fbe-ddeb69438b0b
DOI: 10.1101/723825

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