Article
Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2022
Wang Louise, Desai Heena, Verma Shefali S, Le Anh, Hausler Ryan, Verma Anurag, Judy Renae, Doucette Abigail, Gabriel Peter E, Nathanson Katherine L, Damrauer Scott M, Mowery Danielle L, Ritchie Marylyn D, Kember Rachel L, Maxwell Kara N
Abstract excerpt
PURPOSE: Genome-wide association studies have identified hundreds of single nucleotide variations (formerly single nucleotide polymorphisms) associated with several cancers, but the predictive ability of polygenic risk scores (PRSs) is unclear, especially among non-Whites. METHODS: PRSs were derived from genome-wide significant single-nucleotide variations for 15 cancers in 20,079 individuals in an academic...
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