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Article

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.

Nature communications - 27 Nov 2020

Kachuri Linda, Graff Rebecca E, Smith-Byrne Karl, Meyers Travis J, Rashkin Sara R, Ziv Elad, Witte John S, Johansson Mattias

Abstract excerpt

Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify the added predictive value of integrating cancer-specific PRS with family history and modifiable risk...

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Identifiers

PMID: 33247094
DOI: 10.1038/s41467-020-19600-4
PMCID: PMC7695829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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