Article

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

2020-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Cancer risk is determined by a complex interplay of environmental and heritable factors. Polygenic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for disease prediction. Using data from the UK Biobank (413,753 individuals; 22,755 incident cancer cases), we quantify the added predictive value of integrating cancer-specific PRS with family history and...

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Literature Corpus work: ae2d22d3-f6ff-5d1d-8705-aa3bbae2371e
DOI: 10.1101/2020.01.28.922088

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