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Article

Utility of polygenic risk scores in UK cancer screening: a modelling analysis.

The Lancet. Oncology - 1 Jun 2023

Huntley Catherine, Torr Bethany, Sud Amit, Rowlands Charlie F, Way Rosalind, Snape Katie, Hanson Helen, Swanton Charles, Broggio John, Lucassen Anneke, McCartney Margaret, Houlston Richard S, Hingorani Aroon D, Jones Michael E, Turnbull Clare

Abstract excerpt

BACKGROUND: It is proposed that, through restriction to individuals delineated as high risk, polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer screening programmes and enable extension into new age ranges and disease types. To address this proposition, we present an overview of the performance of PRS tools (ie, models and sets of single nucleotide polymorphisms) alongside harms...

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PMID: 37178708
DOI: 10.1016/S1470-2045(23)00156-0

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