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Article

FOXP3 deficiency, from the mechanisms of the disease to curative strategies.

Immunological reviews - 1 Mar 2024

Borna Simon, Meffre Eric, Bacchetta Rosa

Abstract excerpt

FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome (IPEX), a prototypic primary immune regulatory disorder (PIRD) with defective regulatory T (Treg) cells. Although life-threatening, the increased awareness and early diagnosis have contributed to improved control of the disease. IPEX currently...

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PMID: 37994657
DOI: 10.1111/imr.13289

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