Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.

doi:10.1038/s41590-021-00910-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.

Nature immunology - 1 May 2021

Zemmour David, Charbonnier Louis-Marie, Leon Juliette, Six Emmanuelle, Keles Sevgi, Delville Marianne, Benamar Mehdi, Baris Safa, Zuber Julien, Chen Karin, Neven Benedicte, Garcia-Lloret Maria I, Ruemmele Frank M, Brugnara Carlo, Cerf-Bensussan Nadine, Rieux-Laucat Frederic, Cavazzana Marina, André Isabelle, Chatila Talal A, Mathis Diane, Benoist Christophe

Abstract excerpt

FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by altering regulatory T (Treg) cells. CD4+ T cells in patients with IPEX syndrome and Foxp3-deficient mice were analyzed by single-cell cytometry and RNA-sequencing, revealing heterogeneous Treg-like cells, some very similar to normal Treg cells, others more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Datasets as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diarrhea

Share to Forkhead Transcription Factors

Share to Genetic Diseases, X-Linked

Share to Immune System Diseases

Share to RNA-Seq

Share to Single-Cell Analysis

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 33833438
DOI: 10.1038/s41590-021-00910-8
PMCID: PMC8173714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.PMID 33833438Read ↗

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 <sup>+</sup> T cell perturbationsSemantic proximity Read ↗

FOXP3 deficiency, from the mechanisms of the disease to curative strategies.Semantic proximity Read ↗

Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction.Semantic proximity Read ↗

Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations.Semantic proximity Read ↗

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.Semantic proximity Read ↗

Beyond the Classical Triad: Atypical Presentations and Regulatory T Cell Phenotyping in a Cohort of IPEX Patients.Semantic proximity Read ↗

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.Semantic proximity Read ↗

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.Semantic proximity Read ↗

Defective regulatory and effector T cell functions in patients with FOXP3 mutations.Semantic proximity Read ↗

The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.Semantic proximity Read ↗

IPEX due to an exon 7 skipping FOXP3 mutation with autoimmune diabetes mellitus cured by selective TReg cell engraftment.Semantic proximity Read ↗

Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.