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Mutations induced by Bleomycin, 4-nitroquinoline-1-oxide, and hydrogen peroxide in the rpoB gene of Escherichia coli: Perspective on Mutational Hotspots.

Mutation research - 1 Jan 2000

Fernandez Kristen, D'Souza Sara, Ahn Jenny J, Singh Summer, Bacasen Erin Mae, Mashiach Daniel, Mishail Daniel, Kao Timothy, Thai Jasmine, Hwang Spring, Yaramada Lekha, Miller Jeffrey H

Abstract excerpt

We report the mutational spectra in a segment of the E. coli rpoB gene of bleomycin (BLEO), 4-nitroquinoline-1-oxide (NQO), and hydrogen peroxide (H2O2). We compare these spectra with those of other mutagens and repair deficient strains in the same rpoB system, and review the key elements determining mutational hotspots and outline the questions that remain unanswered. We consider three tiers of hotspots that...

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PMID: 32422468
DOI: 10.1016/j.mrfmmm.2020.111702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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