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Article

Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli.

Cell reports - 25 Oct 2012

Shee Chandan, Gibson Janet L, Rosenberg Susan M

Abstract excerpt

Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure. We report that DNA double-strand breaks (DSBs) provoke mutation hotspots via stress-induced mutation in Escherichia coli. With tet reporters placed 2 kb to 2 Mb (half the genome) away from an I-SceI site, RpoS/DinB-dependent mutations occur maximally within the...

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Identifiers

PMID: 23041320
DOI: 10.1016/j.celrep.2012.08.033
PMCID: PMC3607216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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