Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.

doi:10.1074/jbc.271.31.18368

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Article

Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.

The Journal of biological chemistry - 2 Aug 1996

Solomon M S, Morgenthaler P M, Turesky R J, Essigmann J M

Abstract excerpt

The mutagenic specificity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline (MeIQx), a food-borne mutagen and carcinogen, was studied. Plasmid pK19 was modified by photolysis with the 2-azido form of the carcinogen. High pressure liquid chromatography confirmed that the photoactivated azide forme...

Topics

Base Sequence
Binding Sites
Carcinogens
DNA Adducts
DNA, Bacterial
DNA-Directed DNA Polymerase
Escherichia coli
Lac Operon
Molecular Sequence Data
Molecular Structure
Mutagens
Mutation
Quinoxalines
R Factors

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