Article
Anatomy of a hotspot: Cisplatin hotspots in the tdk gene of Escherichia coli.
Environmental and molecular mutagenesis - 1 Nov 2024
Young Courtney, Lee Mackenzie, Ge Zoe, Shin Jeana, Bursulaya Bella, Sorensen Dana, Saud Arnav, Sridharan Ananya, Gonick Ava, Phi Nhu, Nguyen Kelly, Bhalli Shawal, Hiranandani Jyotsna, Miller Jeffrey H
Abstract excerpt
We previously reported that certain sub-regions of the thyA gene of Escherichia coli are more mutable than others when many different mutagens and mutators are analyzed (Mashiach et al., Mutation Research Fundamental Molecular Mechansims of Mutagenesis, 821: 111702, 2021). In this study, we focus on a single mutagen, cisplatin and verify that mutations occur preferentially at specific 3 bp sequences, but only...
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