Article
In search of a mutational hotspot.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Hatahet Z, Zhou M, Reha-Krantz L J, Morrical S W, Wallace S S
Abstract excerpt
In vitro selection was used to define sequence contexts that significantly enhanced the mutagenic potential of 7, 8-dihydro-8-oxoguanine (8-oxoG). Contexts that simultaneously reduced the efficiency of 8-oxoG cleavage by formamidopyrimidine DNA N-glycosylase and increased the efficiency of misinc...
Topics
- Bacterial Proteins
- Base Sequence
- Consensus Sequence
- DNA
- DNA Damage
- DNA-Directed DNA Polymerase
- Escherichia coli
- Escherichia coli Proteins
- Factor IX
- Genes, p53
- Guanine
- Humans
- Kinetics
- Lac Repressors
- Molecular Sequence Data
- Mutation
- Repressor Proteins
- Viral Proteins