Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?

The Journal of antimicrobial chemotherapy - 1 May 2005

O'Sullivan Denise M, McHugh Timothy D, Gillespie Stephen H

Abstract excerpt

INTRODUCTION: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA. Various mutations are thought to arise as a consequence, including the oxidation of guanine residues, leading to G?C-->T?A substitution, and oxidation of cytosine resulting in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Mutation

Share to Mycobacterium tuberculosis

Share to Oxidative Stress

Share to Pyrazinamide

Share to Rifampin

Source

Identifiers

PMID: 15814606
DOI: 10.1093/jac/dki069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?PMID 15814606Read ↗

The effect of oxidative stress on the mutation rate of Mycobacterium tuberculosis with impaired catalase/peroxidase function.Semantic proximity Read ↗

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosisSemantic proximity Read ↗

Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru.Semantic proximity Read ↗

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosisSemantic proximity Read ↗

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.Semantic proximity Read ↗

DNA metabolism in mycobacterium tuberculosis: implications for drug resistance and strain variability.Semantic proximity Read ↗

Patterns of compensatory mutations in <i>rpoA/B/C</i> genes of multidrug resistant <i>M. tuberculosis</i> in UgandaSemantic proximity Read ↗

Association between bacterial homoplastic variants and radiological pathology in tuberculosis.Semantic proximity Read ↗

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.Semantic proximity Read ↗

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.Semantic proximity Read ↗

Grave impact of undetected rpoB I572F mutation on clinical course of multidrug-resistant tuberculosis: a case report.Semantic proximity Read ↗

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.