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Article

Insights into mutagenesis using Escherichia coli chromosomal lacZ strains that enable detection of a wide spectrum of mutational events.

Genetics - 1 Jun 2011

Seier Tracey, Padgett Dana R, Zilberberg Gal, Sutera Vincent A, Toha Noor, Lovett Susan T

Abstract excerpt

Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repeat (quasipalindrome, QP) sequences. Using these strains, we demonstrate that mutation of the...

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Identifiers

PMID: 21441210
DOI: 10.1534/genetics.111.127746
PMCID: PMC3122311

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