Article
Single-Cell Analysis Reveals Partial Reactivation of X Chromosome instead of Chromosome-wide Dampening in Naive Human Pluripotent Stem Cells.
Stem cell reports - 12 May 2020
Mandal Susmita, Chandel Deepshikha, Kaur Harman, Majumdar Sudeshna, Arava Maniteja, Gayen Srimonta
Abstract excerpt
Recently, a unique form of X chromosome dosage compensation has been demonstrated in human preimplantation embryos, which happens through the dampening of X-linked gene expression from both X chromosomes. Subsequently, X chromosome dampening has also been demonstrated in female human pluripotent stem cells (hPSCs) during the transition from primed to naive state. However, the existence of dampened X chromosomes...
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