Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.

doi:10.1073/pnas.1917608117

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Article

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2020

Tom Irene, Pham Victoria C, Katschke Kenneth J, Li Wei, Liang Wei-Ching, Gutierrez Johnny, Ah Young Andrew, Figueroa Isabel, Eshghi Shadi Toghi, Lee ChingWei V, Kanodia Jitendra, Snipas Scott J, Salvesen Guy S, Lai Phillip, Honigberg Lee, van Lookeren Campagne Menno, Kirchhofer Daniel, Baruch Amos, Lill Jennie R

Abstract excerpt

Genetic polymorphisms in the region of the trimeric serine hydrolase high-temperature requirement 1 (HTRA1) are associated with increased risk of age-related macular degeneration (AMD) and disease progression, but the precise biological function of HtrA1 in the eye and its contribution to disease etiologies remain undefined. In this study, we have developed an HtrA1-blocking Fab fragment to test the therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32345717
DOI: 10.1073/pnas.1917608117
PMCID: PMC7211935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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