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Article

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome.

Investigative ophthalmology & visual science - 1 Jul 2010

An Eunkyung, Sen Supti, Park Sung Kyu, Gordish-Dressman Heather, Hathout Yetrib

Abstract excerpt

PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu. METHODS. Primary RPE cell cultures were established from human don...

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Source

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Identifiers

PMID: 20207970
DOI: 10.1167/iovs.09-4853
PMCID: PMC2904004

Genes

HTRA1
RPE
ADAM9
ARMS2
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20207970-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome.PMID 20207970Read ↗

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AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia.Semantic proximity Read ↗

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read ↗

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