Article
HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration.
The Journal of biological chemistry - 30 Jan 2015
Iejima Daisuke, Itabashi Takeshi, Kawamura Yuich, Noda Toru, Yuasa Shinsuke, Fukuda Keiichi, Oka Chio, Iwata Takeshi
Abstract excerpt
Dry age-related macular degeneration (AMD) accounts for over 85% of AMD cases in the United States, whereas Japanese AMD patients predominantly progress to wet AMD or polypoidal choroidal vasculopathy. Recent genome-wide association studies have revealed a strong association between AMD and an insertion/deletion sequence between the ARMS2 (age-related maculopathy susceptibility 2) and HTRA1 (high temperature...
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