Human HtrA1 in the archived eyes with age-related macular degeneration.

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Article

Human HtrA1 in the archived eyes with age-related macular degeneration.

Transactions of the American Ophthalmological Society - 1 Jan 2007

Chan Chi-Chao, Shen Defen, Zhou Min, Ross Robert J, Ding Xiaoyan, Zhang Kang, Green W Richard, Tuo Jingsheng

Abstract excerpt

PURPOSE: HtrA1 belongs to the high temperature requirement factor A family of serine proteases, which are involved in protein quality control and cell fate. A single-nucleotide polymorphism (SNP), rs11200638, in the promoter of HtrA1 at chromosome 10q26 is reported as a likely causal variant for age-related macular degeneration (AMD). The SNP is located in the regulatory region and increases production of HtrA1...

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PMID: 18427598
PMCID: PMC2258134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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