A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

doi:10.1126/science.1133811

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Article

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

Science (New York, N.Y.) - 10 Nov 2006

Yang Zhenglin, Camp Nicola J, Sun Hui, Tong Zongzhong, Gibbs Daniel, Cameron D Joshua, Chen Haoyu, Zhao Yu, Pearson Erik, Li Xi, Chien Jeremy, Dewan Andrew, Harmon Jennifer, Bernstein Paul S, Shridhar Viji, Zabriskie Norman A, Hoh Josephine, Howes Kimberly, Zhang Kang

Abstract excerpt

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affects the risk of AMD, but the precise gene(s) have not been identified. We genotyped 581 AMD cases and 309 normal controls in a Caucasian cohort in Utah. We demonstrate that a single-nucleotide polymorphism, rs11200638, in...

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PMID: 17053109
DOI: 10.1126/science.1133811

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HTRA1

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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.PMID 17053109Read ↗

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