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Article

HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.

Molecular and cellular biology - 1 Nov 2012

Kim Goo-Young, Kim Ho-Young, Kim Hyun-Taek, Moon Jeong-Mi, Kim Cheol-Hee, Kang Seongman, Rhim Hyangshuk

Abstract excerpt

Accumulating evidence suggests that HtrA1 (high-temperature requirement A1) is involved in modulating crucial cellular processes and implicated in life-threatening diseases, such as cancer and neuropathological disorders; however, the exact functions of this protease in vivo remain unknown. Here, we show that loss of HtrA1 function increases fibroblast growth factor 8 (FGF8) mRNA levels and triggers activation of...

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Source

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Identifiers

PMID: 22949504
DOI: 10.1128/MCB.00872-12
PMCID: PMC3486155

Genes

FGF8

Provenance

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HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.PMID 22949504Read ↗

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