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Article

Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases

1 Dec 2021

Abstract excerpt

The high temperature requirement factor A1 (HTRA1) is a serine protease which modulates an array of signalling pathways driving basal biological processes. HTRA1 plays a significant role in cell proliferation, migration and fate determination, in addition to controlling protein aggregates through refolding, translocation or degradation. The mutation of HTRA1 has been implicated in a plethora of disorders and this...

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PMID: 35531175
DOI: 10.1016/j.sjbs.2021.11.056

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