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Article

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.

Human molecular genetics - 15 Nov 2015

Friedrich Ulrike, Datta Shyamtanu, Schubert Thomas, Plössl Karolina, Schneider Magdalena, Grassmann Felix, Fuchshofer Rudolf, Tiefenbach Klaus-Jürgen, Längst Gernot, Weber Bernhard H F

Abstract excerpt

High-temperature requirement A1 (HTRA1) is a secreted serine protease reported to play a role in the development of several cancers and neurodegenerative diseases. Still, the mechanism underlying the disease processes largely remains undetermined. In age-related macular degeneration (AMD), a common cause of vision impairment and blindness in industrialized societies, two synonymous polymorphisms (rs1049331:C>T,...

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Identifiers

PMID: 26310622
DOI: 10.1093/hmg/ddv346

Genes

HTRA1
SERPINE1
SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.PMID 26310622Read ↗

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