Article

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> High-temperature requirement protein A1 (HTRA1) is a secreted serine protease with diverse substrates, including extracellular matrix proteins, proteins involved in amyloid deposition, and growth factors. Accordingly, HTRA1 has been implicated in a variety of neurodegenerative diseases including a leading cause of blindness in the elderly, age-related macular degeneration (AMD). In fact, genome...

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Literature Corpus work: 20f662e4-5471-5f22-bf68-ebf7b21fa366
DOI: 10.1101/2025.05.13.651909

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