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Article

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

5 Sept 2022

Abstract excerpt

The trimeric serine protease HTRA1 is a genetic risk factor associated with geographic atrophy (GA), a currently untreatable form of age-related macular degeneration. Here, we describe the allosteric inhibition mechanism of HTRA1 by a clinical Fab fragment, currently being evaluated for GA treatment. Using cryo-EM, X-ray crystallography and biochemical assays we identify the exposed LoopA of HTRA1 as the sole Fab...

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PMID: 36064790
DOI: 10.1038/s41467-022-32760-9

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