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Article

Alternative mechanisms for coordinating polymerase alpha and MCM helicase.

Molecular and cellular biology - 1 Jan 2010

Lee Chanmi, Liachko Ivan, Bouten Roxane, Kelman Zvi, Tye Bik K

Abstract excerpt

Functional coordination between DNA replication helicases and DNA polymerases at replication forks, achieved through physical linkages, has been demonstrated in prokaryotes but not in eukaryotes. In Saccharomyces cerevisiae, we showed that mutations that compromise the activity of the MCM helicase enhance the physical stability of DNA polymerase alpha in the absence of their presumed linker, Mcm10. Mcm10 is an...

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Source

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Identifiers

PMID: 19917723
DOI: 10.1128/MCB.01240-09
PMCID: PMC2798462

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Alternative mechanisms for coordinating polymerase alpha and MCM helicase.PMID 19917723Read ↗

A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.Semantic proximity Read ↗

Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability.Semantic proximity Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

MCM10 and SLD-2/RECQL4 jointly activate the CMG helicase during metazoan DNA replication initiationSemantic proximity Read ↗

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repairSemantic proximity Read ↗

Two mcm3 mutations affect different steps in the initiation of DNA replication.Semantic proximity Read ↗

Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.Semantic proximity Read ↗

Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks.Semantic proximity Read ↗

Interaction between PCNA and diubiquitinated Mcm10 is essential for cell growth in budding yeast.Semantic proximity Read ↗

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