Article
Alternative mechanisms for coordinating polymerase alpha and MCM helicase.
Molecular and cellular biology - 1 Jan 2010
Lee Chanmi, Liachko Ivan, Bouten Roxane, Kelman Zvi, Tye Bik K
Abstract excerpt
Functional coordination between DNA replication helicases and DNA polymerases at replication forks, achieved through physical linkages, has been demonstrated in prokaryotes but not in eukaryotes. In Saccharomyces cerevisiae, we showed that mutations that compromise the activity of the MCM helicase enhance the physical stability of DNA polymerase alpha in the absence of their presumed linker, Mcm10. Mcm10 is an...
Topics
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- DNA Helicases
- DNA Polymerase I
- DNA Replication
- Minichromosome Maintenance Proteins
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins