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A replication stress safeguard provided by the Elg1 Replication Factor C-like complex.

Genetics - 10 Dec 2025

Bose Pallavi, Sau Soumitra

Abstract excerpt

The Elg1 Replication Factor C-like complex (Elg1-RLC) that functions as a proliferating cell nuclear antigen (PCNA) unloader, is known to be involved in multiple DNA replication/repair-related activities from yeast to humans. By exploiting disassembly prone PCNA mutants, we reveal that Elg1-RLC uses its PCNA unloading activity to counter the DNA-alkylating agent methyl-methanesulfonate (MMS)-mediated slow...

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Cell Cycle Proteins
Checkpoint Kinase 2
DNA Damage
DNA Replication
Methyl Methanesulfonate
Proliferating Cell Nuclear Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rad52 DNA Repair and Recombination Protein

Replication Protein C

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Identifiers

PMID: 40985265
DOI: 10.1093/genetics/iyaf196

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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