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Article

The CMG helicase and cancer: a tumor "engine" and weakness with missing mutations.

Oncogene - 1 Feb 2023

Xiang Shengyan, Reed Damon R, Alexandrow Mark G

Abstract excerpt

The replicative Cdc45-MCM-GINS (CMG) helicase is a large protein complex that functions in the DNA melting and unwinding steps as a component of replisomes during DNA replication in mammalian cells. Although the CMG performs this important role in cell growth, the CMG is not a simple bystander in cell cycle events. Components of the CMG, specifically the MCM precursors, are also involved in maintaining genomic...

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Identifiers

PMID: 36522488
DOI: 10.1038/s41388-022-02572-8
PMCID: PMC9948756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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