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Article

Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage.

Molecular biology of the cell - 1 Jan 2005

Green Brian M, Li Joachim J

Abstract excerpt

To maintain genome stability, the entire genome of a eukaryotic cell must be replicated once and only once per cell cycle. In many organisms, multiple overlapping mechanisms block rereplication, but the consequences of deregulating these mechanisms are poorly understood. Here, we show that disrupting these controls in the budding yeast Saccharomyces cerevisiae rapidly blocks cell proliferation. Rereplicating...

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Identifiers

PMID: 15537702
DOI: 10.1091/mbc.e04-09-0833
PMCID: PMC539184

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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