The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

doi:10.1038/nm.3943

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Article

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

Nature medicine - 1 Oct 2015

Ortega-Molina Ana, Boss Isaac W, Canela Andres, Pan Heng, Jiang Yanwen, Zhao Chunying, Jiang Man, Hu Deqing, Agirre Xabier, Niesvizky Itamar, Lee Ji-Eun, Chen Hua-Tang, Ennishi Daisuke, Scott David W, Mottok Anja, Hother Christoffer, Liu Shichong, Cao Xing-Jun, Tam Wayne, Shaknovich Rita, Garcia Benjamin A, Gascoyne Randy D, Ge Kai, Shilatifard Ali, Elemento Olivier, Nussenzweig Andre, Melnick Ari M, Wendel Hans-Guido

Abstract excerpt

The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation in B cells promotes lymphoma development...

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Identifiers

PMID: 26366710
DOI: 10.1038/nm.3943
PMCID: PMC4676270

Genes

SOCS3
TNFAIP3
TNFRSF14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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