Article

USP8 Controls Proteostasis Pathways in B Cells and Multiple Myeloma

2024-04-26

Abstract excerpt

Ubiquitin-specific protease 8 (USP8) is a multifunctional deubiquitinating enzyme that plays a pivotal role in the regulation of endosomal and lysosomal trafficking. Several studies showed that USP8 is critically involved in the pathogenesis of various tumor entities. Recently, USP8 emerged as a vulnerability gene in multiple myeloma (MM), suggesting a functional role in the B- and plasma cell compartment. Here we...

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Literature Corpus work: 6bc8eb77-3bc3-508f-a154-bdaccec00c29
DOI: 10.1101/2024.04.26.591134

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