Article
A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes.
eLife - 7 Apr 2020
KaramiNejadRanjbar Mohammad, Sharifzadeh Sahand, Wietek Nina C, Artibani Mara, El-Sahhar Salma, Sauka-Spengler Tatjana, Yau Christopher, Tresp Volker, Ahmed Ahmed A
Abstract excerpt
Bulk whole genome sequencing (WGS) enables the analysis of tumor evolution but, because of depth limitations, can only identify old mutational events. The discovery of current mutational processes for predicting the tumor's evolutionary trajectory requires dense sequencing of individual clones or single cells. Such studies, however, are inherently problematic because of the discovery of excessive false positive...
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