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Article

Single-Cell Genetic Analysis Using Automated Microfluidics to Resolve Somatic Mosaicism.

PloS one - 1 Jan 2015

Szulwach Keith E, Chen Peilin, Wang Xiaohui, Wang Jing, Weaver Lesley S, Gonzales Michael L, Sun Gang, Unger Marc A, Ramakrishnan Ramesh

Abstract excerpt

Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. Intratumor genetic heterogeneity is inherent to many cancers, creating challenges for effective treatments. Unfortunately, analysis of bulk DNA masks subclonal phylogenetic architectures created by the acquisition and distribution of somatic mutations amongst...

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PMID: 26302375
DOI: 10.1371/journal.pone.0135007
PMCID: PMC4547741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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